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Article

Dysregulation of synaptic plasticity precedes appearance of morphological defects in a Pten conditional knockout mouse model of autism.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2013

Takeuchi Koichi, Gertner Michael J, Zhou Jing, Parada Luis F, Bennett Michael V L, Zukin R Suzanne

Abstract excerpt

The phosphoinositide signaling system is a crucial regulator of neural development, cell survival, and plasticity. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) negatively regulates phosphatidylinositol 3-kinase signaling and downstream targets. Nse-Cre Pten conditional knockout mice, in which Pten is ablated in granule cells of the dentate gyrus and pyramidal neurons of the hippocampal CA3, but...

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Source

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Identifiers

PMID: 23487788
DOI: 10.1073/pnas.1222803110
PMCID: PMC3607034

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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