Article

Discovery of Novel Class of Histone Deacetylase Inhibitors as Anticancer Agents

2021-02-05

Abstract excerpt

Selective inhibition of histone deacetylases (HDACs) is a paramount strategy in the field of anticancer lead drug development. However, the lack of selectivity among these isozymes and the adverse side effects that arise from the inhibition of certain HDACs limits their clinical applications. Phenotypic screening of an in-house pilot library of about 70 small molecules against various HDAC isozymes led to the disc...

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Literature Corpus work: 5bdf1ce8-0b29-5dd7-bc2c-08a498f35ec7
DOI: 10.21203/rs.3.rs-154323/v1

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