Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent.

doi:10.1371/journal.pone.0080848

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Article

Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent.

PloS one - 1 Jan 2013

Nischalke Hans Dieter, Berger Cordula, Lutz Philipp, Langhans Bettina, Wolter Franziska, Eisenhardt Marianne, Krämer Benjamin, Kokordelis Pavlos, Glässner Andreas, Müller Tobias, Rosendahl Jonas, Fischer Janett, Berg Thomas, Grünhage Frank, Leifeld Ludger, Soyka Michael, Nattermann Jacob, Sauerbruch Tilman, Stickel Felix, Spengler Ulrich

Abstract excerpt

BACKGROUND AND AIMS: CXCL1 (CXC chemokine-ligand-1) is a ligand for CXC chemokine receptor 2 expressed on hepatic stellate cells (HSC). Thus, CXCL1 might contribute to HSC activation and fibrogenesis. In the present study, we investigated the influence of the CXCL1 rs4074 polymorphism on the occurrence of alcohol induced liver cirrhosis and hepatocellular carcinoma (HCC). METHODS: The study involved 458 patients...

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Identifiers

PMID: 24260493
DOI: 10.1371/journal.pone.0080848
PMCID: PMC3832473

Genes

CXCL1
TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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