The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients.

doi:10.1016/j.jhep.2011.10.019

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Article

The CXCL1 rs4074 A allele is associated with enhanced CXCL1 responses to TLR2 ligands and predisposes to cirrhosis in HCV genotype 1-infected Caucasian patients.

Journal of hepatology - 1 Apr 2012

Nischalke Hans Dieter, Berger Cordula, Luda Carolin, Müller Tobias, Berg Thomas, Coenen Martin, Krämer Benjamin, Körner Christian, Trebicka Jonel, Grünhage Frank, Lammert Frank, Nattermann Jacob, Sauerbruch Tilman, Spengler Ulrich

Abstract excerpt

BACKGROUND & AIMS: CXCL1 is a ligand for CXC chemokine-receptor 2 expressed on hepatic stellate cells (HSC). Thus, CXCL1 might contribute to HSC activation and fibrogenesis. Here, we investigated whether the CXCL1 rs4074 polymorphism affects CXCL1 expression and progression of chronic hepatitis C virus (HCV) infection towards cirrhosis. METHODS: The study involved 237 patients with chronic HCV genotype 1...

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PMID: 22173151
DOI: 10.1016/j.jhep.2011.10.019

Genes

CXCL1
TLR2

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