Article
Genetic variants of TNFα, IL10, IL1β, CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population.
Gene - 1 Nov 2012
Roy Neelanjana, Mukhopadhyay Indranil, Das Kausik, Pandit Pratap, Majumder Partha P, Santra Amal, Datta Simanti, Banerjee Soma, Chowdhury Abhijit
Abstract excerpt
Alcohol induced liver disease or alcoholic liver disease (ALD), a complex trait, encompasses a gamut of pathophysiological alterations in the liver due to continuous exposure to a toxic amount of alcohol (more than 80 g per day). Of all chronic heavy drinkers, only 15-20% develops hepatitis or cirrhosis concomitantly or in succession. Several studies revealed that inter-individual as well as inter-ethnic genetic...
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