Impact of cytokine gene variants on the prediction and prognosis of hepatocellular carcinoma in patients with cirrhosis.

doi:10.1016/j.jhep.2014.04.011

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Article

Impact of cytokine gene variants on the prediction and prognosis of hepatocellular carcinoma in patients with cirrhosis.

Journal of hepatology - 1 Aug 2014

Tarhuni Arige, Guyot Erwan, Rufat Pierre, Sutton Angela, Bourcier Valérie, Grando Véronique, Ganne-Carrié Nathalie, Ziol Marianne, Charnaux Nathalie, Beaugrand Michel, Moreau Richard, Trinchet Jean-Claude, Mansouri Abdellah, Nahon Pierre

Abstract excerpt

BACKGROUND & AIMS: Genetic polymorphisms modulate the expression of proinflammatory cytokines. We prospectively assessed the influence of 6 single nucleotide polymorphisms (SNPs) in TNFα, IL6, and IL1β genes on the risk of hepatocellular carcinoma (HCC) in patients with cirrhosis. METHODS: TNFα (...

Topics

Carcinoma, Hepatocellular
Cytokines
Female
Humans
Interleukin-1beta
Liver Cirrhosis
Liver Neoplasms
Male
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Tumor Necrosis Factor-alpha

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Identifiers

PMID: 24751829
DOI: 10.1016/j.jhep.2014.04.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24751829-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.