Influence of polymorphisms in TNF-α and IL1β on susceptibility to alcohol induced liver diseases and therapeutic potential of miR-124-3p impeding TNF-α/IL1β mediated multi-cellular signaling in liver microenvironment.

doi:10.3389/fimmu.2023.1241755

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Article

Influence of polymorphisms in TNF-α and IL1β on susceptibility to alcohol induced liver diseases and therapeutic potential of miR-124-3p impeding TNF-α/IL1β mediated multi-cellular signaling in liver microenvironment.

Frontiers in immunology - 1 Jan 2023

Dasgupta Debanjali, Ghosh Suchandrima, Dey Indrashish, Majumdar Swagata, Chowdhury Saheli, Das Subhas, Banerjee Sanjana, Saha Mehelana, Ghosh Amit, Roy Neelanjana, Manna Alak, Ray Sukanta, Agarwal Shaleen, Bhaumik Pradeep, Datta Simanti, Chowdhury Abhijit, Banerjee Soma

Abstract excerpt

Background and aims: Alcoholic liver disease (ALD) is the leading cause of the liver cirrhosis related death worldwide. Excessive alcohol consumption resulting enhanced gut permeability which trigger sensitization of inflammatory cells to bacterial endotoxins and induces secretion of cytokines, chemokines leading to activation of stellate cells, neutrophil infiltration and hepatocyte injury followed by...

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PMID: 38146363
DOI: 10.3389/fimmu.2023.1241755
PMCID: PMC10749309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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