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Article

Stromal cell-derived factor-1 but not its receptor, CXCR4, gene variants increase susceptibility and pathological development of hepatocellular carcinoma.

Clinical chemistry and laboratory medicine - 1 Jan 2009

Chang Chi-Chung, Chen Shu-Chen, Hsieh Yi-Hsien, Chen Yi-Chen, Chen Tzy-Yen, Chu Yin-Hung, Ma Hui-Jen, Chou Ming-Chih, Tsai Hsiu-Ting, Yang Shun-Fa

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide. Genetic polymorphism has been reported as a predictive factor related to a higher risk for HCC. Because the stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been reported to play important roles in tumor cell proliferation, angiogenesis, and metastasis of HCC, the aim of this study was to...

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Share to Biomarkers, Tumor
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CXCL12

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Polymorphism, Genetic

Share to Receptors, CXCR4

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Source

Identifiers

PMID: 19327121
DOI: 10.1515/CCLM.2009.092

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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