Article
Polymorphisms in the IL-1 gene cluster influence systemic inflammation in patients at risk for acute-on-chronic liver failure.
Hepatology (Baltimore, Md.) - 1 Jan 2017
Alcaraz-Quiles José, Titos Esther, Casulleras Mireia, Pavesi Marco, López-Vicario Cristina, Rius Bibiana, Lopategi Aritz, de Gottardi Andrea, Graziadei Ivo, Gronbaek Henning, Ginès Pere, Bernardi Mauro, Arroyo Vicente, Clària Joan
Abstract excerpt
Acute-on-chronic liver failure (ACLF) in cirrhosis is an increasingly recognized syndrome characterized by acute decompensation, organ failure(s) and high short-term mortality. Recent findings suggest that an overexuberant systemic inflammation plays a primary role in ACLF progression. In this study, we examined whether genetic factors shape systemic immune responses in patients with decompensated cirrhosis. Six...
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