Article
The structural gene coding for myelin-associated proteolipid protein is mutated in jimpy mice.
Nature - 1 Jan 2000
Dautigny A, Mattei M G, Morello D, Alliel P M, Pham-Dinh D, Amar L, Arnaud D, Simon D, Mattei J F, Guenet J L
Abstract excerpt
Mutations affecting developmental processes may allow some insight into the complexity of the biological processes involved. In mice, two mutants that affect myelin formation in the central nervous system, jimpy and shiverer, have proved to be useful models for the study of this process. The predominant proteins in myelin are the major myelin proteolipid (PLP) and the myelin basic proteins (MBP), which together...
Topics
- Animals
- Brain Chemistry
- Chromosome Deletion
- DNA
- DNA Restriction Enzymes
- Female
- Genes
- Haploidy
- Karyotyping
- Male
- Mice
- Mice, Jimpy