Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jimpy-4J mouse has a missense mutation in exon 2 of the Plp gene.

Developmental neuroscience - 1 Jan 1997

Pearsall G B, Nadon N L, Wolf M K, Billings-Gagliardi S

Abstract excerpt

We previously showed that the jimpy-4J mouse mutation is located on the X chromosome, in or closely linked to the proteolipid protein (Plp) gene. The phenotype is characterized by the most severe hypomyelination of any of the naturally occurring myelin mutant mice, sharp reduction in oligodendrocyte number, and virtual absence of PLP protein. Affected animals show tremor, seizures, and die at about 24 postnatal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Northern
Share to DNA
Share to DNA Primers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phenotype

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9215879
DOI: 10.1159/000111230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jimpy-4J mouse has a missense mutation in exon 2 of the Plp gene.PMID 9215879Read ↗

Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.Semantic proximity Read ↗

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

Current concepts of PLP and its role in the nervous system.Semantic proximity Read ↗

A point mutation in the proteolipid protein gene of the 'shaking pup' interrupts oligodendrocyte development.Semantic proximity Read ↗

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.Semantic proximity Read ↗

A de novo splice donor site mutation causes in-frame deletion of 14 amino acids in the proteolipid protein in Pelizaeus-Merzbacher disease.Semantic proximity Read ↗

The proteolipid protein gene and myelin disorders in man and animal models.Semantic proximity Read ↗

The evolution of lipophilin genes from invertebrates to tetrapods: DM-20 cannot replace proteolipid protein in CNS myelin.Semantic proximity Read ↗

Transgenic and natural mouse models of proteolipid protein (PLP)-related dysmyelination and demyelination.Semantic proximity Read ↗

Rumpshaker-like proteolipid protein (PLP) ratio in a mouse model with unperturbed structural and functional integrity of the myelin sheath and axons in the central nervous system.Semantic proximity Read ↗

Age-related axonal and myelin changes in the rumpshaker mutation of the Plp gene.Semantic proximity Read ↗

Trembler mouse carries a point mutation in a myelin gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.