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Article

Proteolipid protein: is it more than just a structural component of myelin?

Developmental neuroscience - 1 Jan 1996

Knapp P E

Abstract excerpt

Proteolipid protein (PLP) is the most abundant protein of central nervous system (CNS) myelin. Because of its predicted topography, PLP has been assumed to function as a structural component of myelin, providing stability and maintaining the compact lamellar structure. However, developmental studies have shown that the PLP gene is active long before myelination begins. This and other evidence from various PLP...

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PMID: 8911768
DOI: 10.1159/000111420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Proteolipid protein: is it more than just a structural component of myelin?PMID 8911768Read ↗

Current concepts of PLP and its role in the nervous system.Semantic proximity Read ↗

Many naturally occurring mutations of myelin proteolipid protein impair its intracellular transportSemantic proximity Read ↗

Fatty acid binding protein-8 (FABP8/PMP2) reveals molecular heterogeneity of myelin sheaths in the human CNSSemantic proximity Read ↗

The pathobiology of myelin mutants reveal novel biological functions of the MBP and PLP genes.Semantic proximity Read ↗

Pelizaeus-Merzbacher disease.Semantic proximity Read ↗

Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system.Semantic proximity Read ↗

The molecular genetics of myelination: an update.Semantic proximity Read ↗

Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

Novel molecular insights into the critical role of sulfatide in myelin maintenance/function.Semantic proximity Read ↗

Pelizaeus-Merzbacher disease: pathogenic mechanisms and insights into the roles of proteolipid protein 1 in the nervous system.Semantic proximity Read ↗

Insertion of proteolipid protein into oligodendrocyte mitochondria regulates extracellular pH and adenosine triphosphate.Semantic proximity Read ↗

Pelizaeus-Merzbacher Disease: Molecular and Cellular Pathologies and Associated Phenotypes.Semantic proximity Read ↗

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