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Article

Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.

Brain research. Brain research reviews - 1 Mar 1998

Vela J M, González B, Castellano B

Abstract excerpt

Jimpy is a shortened life-span murine mutant showing recessive sex-linked inheritance. The genetic defect consists of a point mutation in the PLP gene and produces a severe CNS myelin deficiency that is associated with a variety of complex abnormalities affecting all glial populations. The myelin deficiency is primarily due to a failure to produce the normal amount of myelin during development. However, myelin...

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PMID: 9600623
DOI: 10.1016/s0165-0173(97)00055-6

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Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.PMID 9600623Read ↗

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Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.Semantic proximity Read ↗

A combination of PLP and DM20 transgenes promotes partial myelination in the jimpy mouse.Semantic proximity Read ↗

Epigenetic factors up-regulate expression of myelin proteins in the dysmyelinating jimpy mutant mouse.Semantic proximity Read ↗

Evidence that CNS hypomyelination does not cause death of jimpy-msd mutant mice.Semantic proximity Read ↗

Rumpshaker: an X-linked mutation causing hypomyelination: developmental differences in myelination and glial cells between the optic nerve and spinal cord.Semantic proximity Read ↗

Effects of the jimpy mutation on mouse retinal structure and function.Semantic proximity Read ↗

Genetic background determines phenotypic severity of the Plp rumpshaker mutation.Semantic proximity Read ↗

Differential expression of apoptotic markers in jimpy and in Plp overexpressors: evidence for different apoptotic pathways.Semantic proximity Read ↗

Oligodendrocyte development and differentiation in the rumpshaker mutation.Semantic proximity Read ↗

Early onset of axonal degeneration in double (plp-/-mag-/-) and hypomyelinosis in triple (plp-/-mbp-/-mag-/-) mutant mice.Semantic proximity Read ↗

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