Article
Understanding glial abnormalities associated with myelin deficiency in the jimpy mutant mouse.
Brain research. Brain research reviews - 1 Mar 1998
Vela J M, González B, Castellano B
Abstract excerpt
Jimpy is a shortened life-span murine mutant showing recessive sex-linked inheritance. The genetic defect consists of a point mutation in the PLP gene and produces a severe CNS myelin deficiency that is associated with a variety of complex abnormalities affecting all glial populations. The myelin...
Topics
- Animals
- Demyelinating Diseases
- Mice
- Mice, Jimpy
- Mutation
- Myelin Sheath
- Neuroglia