Article
Current concepts of PLP and its role in the nervous system.
Microscopy research and technique - 1 Jun 1998
Griffiths I, Klugmann M, Anderson T, Thomson C, Vouyiouklis D, Nave K A
Abstract excerpt
Proteolipid protein (PLP) and its smaller isoform DM20 constitute the major myelin proteins of the CNS. Mutations of the X-linked Plp gene cause the heterogeneous syndromes of Pelizaeus-Merzbacher disease (PMD) and spastic paraplegia (SPG) in man and similar dysmyelinating disorders in a range of animal species. A variety of mutations including missense mutations, deletions, and duplications are responsible....
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