Conservative amino acid substitution in the myelin proteolipid protein of jimpymsd mice.

Abstract excerpt

The capacity for synthesizing and maintaining a compact myelin sheath is destroyed in a number of inborn errors of myelin metabolism. One class of hypomyelinating mutations, which displays an X-linked pattern of inheritance, is distinguished by marked disturbances in oligodendrocyte differentiation. We have defined the molecular defect in one such mutant that lacks mature oligodendrocytes, the X-linked jimpy...

Topics

• Amino Acid Sequence
• Animals
• Chromosome Mapping
• Exons
• Mice
• Mice, Jimpy
• Mice, Neurologic Mutants
• Molecular Sequence Data
• Mutation
• Myelin Proteins
• Myelin Proteolipid Protein