Article
Uncoupling of hypomyelination and glial cell death by a mutation in the proteolipid protein gene.
Nature - 27 Aug 1992
Schneider A, Montague P, Griffiths I, Fanarraga M, Kennedy P, Brophy P, Nave K A
Abstract excerpt
Proteolipid protein (PLP; M(r) 30,000) is a highly conserved major polytopic membrane protein in myelin but its cellular function remains obscure. Neurological mutant mice can often provide model systems for human genetic disorders. Mutations of the X-chromosome-linked PLP gene are lethal, identi...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Death
- Demyelinating Diseases
- Diffuse Cerebral Sclerosis of Schilder
- Membrane Proteins
- Mice
- Mice, Neurologic Mutants
- Molecular Sequence Data
- Mutation
- Myelin Proteins
- Myelin Proteolipid Protein
- Neuroglia
- Structure-Activity Relationship