Article
NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study.
Blood - 23 Apr 2009
Asnafi Vahid, Buzyn Agnès, Le Noir Sandrine, Baleydier Frédéric, Simon Arnauld, Beldjord Kheira, Reman Oumedaly, Witz Francis, Fagot Thierry, Tavernier Emmanuelle, Turlure Pascal, Leguay Thibaut, Huguet Françoise, Vernant Jean-Paul, Daniel Francis, Béné Marie-Christine, Ifrah Norbert, Thomas Xavier, Dombret Hervé, Macintyre Elizabeth
Abstract excerpt
Many somatic genetic abnormalities have been identified in T-cell acute lymphoblastic leukemia (T-ALL) but each individual abnormality accounts for a small proportion of cases; therapeutic stratification consequently still relies on classical clinical markers. NOTCH1 and/or FBXW7 mutations both lead to activation of the NOTCH1 pathway and are among the most frequent mutations in T-ALL. We screened 141 adult...
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