Article
NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols.
Leukemia - 1 Dec 2010
Zuurbier L, Homminga I, Calvert V, te Winkel M L, Buijs-Gladdines J G C A M, Kooi C, Smits W K, Sonneveld E, Veerman A J P, Kamps W A, Horstmann M, Petricoin E F, Pieters R, Meijerink J P P
Abstract excerpt
Aberrant activation of the NOTCH1 pathway by inactivating and activating mutations in NOTCH1 or FBXW7 is a frequent phenomenon in T-cell acute lymphoblastic leukemia (T-ALL). We retrospectively investigated the relevance of NOTCH1/FBXW7 mutations for pediatric T-ALL patients enrolled on Dutch Chi...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.