Article
The favorable effect of activating NOTCH1 receptor mutations on long-term outcome in T-ALL patients treated on the ALL-BFM 2000 protocol can be separated from FBXW7 loss of function.
Leukemia - 1 Dec 2010
Kox C, Zimmermann M, Stanulla M, Leible S, Schrappe M, Ludwig W-D, Koehler R, Tolle G, Bandapalli O R, Breit S, Muckenthaler M U, Kulozik A E
Abstract excerpt
Precursor T-cell acute lymphoblastic leukemia (T-ALL) remains an important challenge in pediatric oncology. Because of the particularly poor prognosis of relapses, it is vital to identify molecular risk factors allowing early and effective treatment stratification. Activating NOTCH1 mutations sig...
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