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Article

Prognostic implications of mutations in NOTCH1 and FBXW7 in childhood T-ALL treated according to the NOPHO ALL-1992 and ALL-2000 protocols.

Pediatric blood & cancer - 1 Mar 2014

Fogelstrand Linda, Staffas Anna, Wasslavik Carina, Sjögren Helene, Söderhäll Stefan, Frost Britt-Marie, Forestier Erik, Degerman Sofie, Behrendtz Mikael, Heldrup Jesper, Karrman Kristina, Johansson Bertil, Heyman Mats, Abrahamsson Jonas, Palmqvist Lars

Abstract excerpt

BACKGROUND: In children, T-cell acute lymphoblastic leukemia (T-ALL) has inferior prognosis compared with B-cell precursor ALL. In order to improve survival, individualized treatment strategies and thus risk stratification algorithms are warranted, ideally already at the time of diagnosis. PROCEDURE: We analyzed the frequency and prognostic implication of mutations in NOTCH1 and FBXW7 in 79 cases of Swedish...

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Source

Identifiers

PMID: 24424791
DOI: 10.1002/pbc.24803

Genes

NOTCH1
HES1
MYB
EFS
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prognostic implications of mutations in NOTCH1 and FBXW7 in childhood T-ALL treated according to the NOPHO ALL-1992 and ALL-2000 protocols.PMID 24424791Read ↗

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Prognostic significance of NOTCH1/FBXW7 mutations in pediatric T cell acute lymphoblastic leukemia: a study of minimal residual disease risk-directed CCLG-ALL 2008 treatment protocol.Semantic proximity Read ↗

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Identification of novel NOTCH1 mutations: increasing our knowledge of the NOTCH signaling pathway.Semantic proximity Read ↗

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