Article
Sex- and age-interacting eQTLs in human complex diseases.
Human molecular genetics - 1 Apr 2014
Yao Chen, Joehanes Roby, Johnson Andrew D, Huan Tianxiao, Esko Tõnu, Ying Saixia, Freedman Jane E, Murabito Joanne, Lunetta Kathryn L, Metspalu Andres, Munson Peter J, Levy Daniel
Abstract excerpt
Many complex human diseases exhibit sex or age differences in gene expression. However, the presence and the extent of genotype-specific variations in gene regulation are largely unknown. Here, we report results of a comprehensive analysis of expression regulation of genetic variation related to 11,672 complex disease-associated SNPs as a function of sex and age in whole-blood-derived RNA from 5254 individuals....
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