Article
Genotype×age interaction in human transcriptional ageing.
Mechanisms of ageing and development - 1 Jan 2000
Kent Jack W, Göring Harald H H, Charlesworth Jac C, Drigalenko Eugene, Diego Vincent P, Curran Joanne E, Johnson Matthew P, Dyer Thomas D, Cole Shelley A, Jowett Jeremy B M, Mahaney Michael C, Comuzzie Anthony G, Almasy Laura, Moses Eric K, Blangero John, Williams-Blangero Sarah
Abstract excerpt
Individual differences in biological ageing (i.e., the rate of physiological response to the passage of time) may be due in part to genotype-specific variation in gene action. However, the sources of heritable variation in human age-related gene expression profiles are largely unknown. We have profiled genome-wide expression in peripheral blood mononuclear cells from 1240 individuals in large families and found...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.