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Article

Sex-heterogeneous SNPs disproportionately influence gene expression and health.

PLoS genetics - 1 May 2022

Traglia Michela, Bout Margaux, Weiss Lauren A

Abstract excerpt

Phenotypic differences across sexes are pervasive, but the genetic architecture of sex differences within and across phenotypes is mostly unknown. In this study, we aimed to improve detection power for sex-differentially contributing SNPs previously demonstrated to be enriched in disease association, and we investigate their functions in health, pathophysiology, and genetic function. We leveraged GIANT and UK...

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PMID: 35511767
DOI: 10.1371/journal.pgen.1010147
PMCID: PMC9070888

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MAF

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