Article
Sex-biased genetic effects on gene regulation in humans.
Genome research - 1 Dec 2012
Dimas Antigone S, Nica Alexandra C, Montgomery Stephen B, Stranger Barbara E, Raj Towfique, Buil Alfonso, Giger Thomas, Lappalainen Tuuli, Gutierrez-Arcelus Maria, McCarthy Mark I, Dermitzakis Emmanouil T
Abstract excerpt
Human regulatory variation, reported as expression quantitative trait loci (eQTLs), contributes to differences between populations and tissues. The contribution of eQTLs to differences between sexes, however, has not been investigated to date. Here we explore regulatory variation in females and males and demonstrate that 12%-15% of autosomal eQTLs function in a sex-biased manner. We show that genes possessing...
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