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Article

The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs.

Nature immunology - 1 Jan 2014

McFarland Adelle P, Horner Stacy M, Jarret Abigail, Joslyn Rochelle C, Bindewald Eckart, Shapiro Bruce A, Delker Don A, Hagedorn Curt H, Carrington Mary, Gale Michael, Savan Ram

Abstract excerpt

IFNL3, which encodes interferon-λ3 (IFN-λ3), has received considerable attention in the hepatitis C virus (HCV) field, as many independent genome-wide association studies have identified a strong association between polymorphisms near IFNL3 and clearance of HCV. However, the mechanism underlying this association has remained elusive. In this study, we report the identification of a functional polymorphism...

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Identifiers

PMID: 24241692
DOI: 10.1038/ni.2758
PMCID: PMC4183367

Genes

IFNL3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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