Article
The role of cannabinoid 1 receptor expressing interneurons in behavior.
Neurobiology of disease - 1 Mar 2014
Brown Jacquelyn A, Horváth Szatmár, Garbett Krassimira A, Schmidt Martin J, Everheart Monika, Gellért Levente, Ebert Philip, Mirnics Károly
Abstract excerpt
Schizophrenia is a devastating neurodevelopmental disorder that affects approximately 1% of the population. Reduced expression of the 67-kDa protein isoform of glutamic acid decarboxylase (GAD67) is a hallmark of the disease and is encoded by the GAD1 gene. In schizophrenia, GAD67 downregulation occurs in multiple interneuronal subpopulations, including the cannabinoid receptor type 1 positive (CNR1+) cells, but...
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