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Article

Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition.

Nature communications - 12 Jan 2021

Wang Yao-Yi, Zhao Bing, Wu Meng-Meng, Zheng Xiao-Li, Lin Longnian, Yin Dong-Min

Abstract excerpt

Cortical disinhibition is a common feature of several neuropsychiatric diseases such as schizophrenia, autism and intellectual disabilities. However, the underlying mechanisms are not fully understood. To mimic increased expression of Nrg1, a schizophrenia susceptibility gene in GABAergic interneurons from patients with schizophrenia, we generated gtoNrg1 mice with overexpression of Nrg1 in GABAergic...

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Identifiers

PMID: 33436636
DOI: 10.1038/s41467-020-20552-y
PMCID: PMC7804852

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