Article
Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2018
Kolata Stefan M, Nakao Kazuhito, Jeevakumar Vivek, Farmer-Alroth Emily L, Fujita Yuko, Bartley Aundrea F, Jiang Sunny Zhihong, Rompala Gregory R, Sorge Robert E, Jimenez Dennisse V, Martinowich Keri, Mateo Yolanda, Hashimoto Kenji, Dobrunz Lynn E, Nakazawa Kazu
Abstract excerpt
Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. We modeled cortical GAD67 reduction in mice, in which the Gad1 gene is genetically ablated from ~50% of cortical and hippocampal interneurons. Mutant mice showed a reduction of tissue GABA in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.