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Article

Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders.

Brain research reviews - 1 Sept 2006

Akbarian Schahram, Huang Hsien-Sung

Abstract excerpt

The 67 and 65 kDa isoforms of glutamic acid decarboxylase, the key enzymes for GABA biosynthesis, are expressed at altered levels in postmortem brain of subjects diagnosed with schizophrenia and related disorders, including autism and bipolar illness. The predominant finding is a decrease in GAD67 mRNA levels, affecting multiple brain regions, including prefrontal and temporal cortex. Postmortem studies, in...

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Source

Identifiers

PMID: 16759710
DOI: 10.1016/j.brainresrev.2006.04.001

Genes

GAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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