Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of transgenic mice overexpressing neuregulin-1.

PloS one - 9 Dec 2010

Kato Taisuke, Kasai Atsushi, Mizuno Makoto, Fengyi Liang, Shintani Norihito, Maeda Sadaaki, Yokoyama Minesuke, Ozaki Miwako, Nawa Hiroyuki

Abstract excerpt

BACKGROUND: Neuregulin-1 (NRG1) is one of the susceptibility genes for schizophrenia and implicated in the neurotrophic regulation of GABAergic and dopaminergic neurons, myelination, and NMDA receptor function. Postmortem studies often indicate a pathologic association of increased NRG1 expression or signaling with this illness. However, the psychobehavioral implication of NRG1 signaling has mainly been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dopamine

Share to Frontal Lobe

Share to Gene Expression Regulation

Share to Mice, Transgenic

Share to Neuregulin-1

Share to Neuroglia

Source

Open in PubMed Open full text

Identifiers

PMID: 21151609
DOI: 10.1371/journal.pone.0014185
PMCID: PMC3000321

Genes

NRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of transgenic mice overexpressing neuregulin-1.PMID 21151609Read ↗

Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in MiceSemantic proximity Read ↗

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia ModelSemantic proximity Read ↗

Behavioral profile of a heterozygous mutant mouse model for EGF-like domain neuregulin 1.Semantic proximity Read ↗

Disruption to social dyadic interactions but not emotional/anxiety-related behaviour in mice with heterozygous 'knockout' of the schizophrenia risk gene neuregulin-1.Semantic proximity Read ↗

Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1.Semantic proximity Read ↗

Reversible overexpression of bace1-cleaved neuregulin-1 N-terminal fragment induces schizophrenia-like phenotypes in mice.Semantic proximity Read ↗

Cognition in transmembrane domain neuregulin 1 mutant mice.Semantic proximity Read ↗

Disruption of the neuregulin 1 gene in the rat alters HPA axis activity and behavioral responses to environmental stimuli.Semantic proximity Read ↗

Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.Semantic proximity Read ↗

NRG1 knockdown rescues PV interneuron GABAergic maturation deficits and schizophrenia behaviors in fetal growth restriction miceSemantic proximity Read ↗

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.Semantic proximity Read ↗

Altered motor activity, exploration and anxiety in heterozygous neuregulin 1 mutant mice: implications for understanding schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.