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Article

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.

The Journal of clinical investigation - 1 Dec 2013

Kansara Maya, Leong Huei San, Lin Dan Mei, Popkiss Sophie, Pang Puiyi, Garsed Dale W, Walkley Carl R, Cullinane Carleen, Ellul Jason, Haynes Nicole M, Hicks Rod, Kuijjer Marieke L, Cleton-Jansen Anne-Marie, Hinds Philip W, Smyth Mark J, Thomas David M

Abstract excerpt

Ionizing radiation (IR) and germline mutations in the retinoblastoma tumor suppressor gene (RB1) are the strongest risk factors for developing osteosarcoma. Recapitulating the human predisposition, we found that Rb1+/- mice exhibited accelerated development of IR-induced osteosarcoma, with a latency of 39 weeks. Initial exposure of osteoblasts to carcinogenic doses of IR in vitro and in vivo induced RB1-dependent...

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Share to Bone Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24231354
DOI: 10.1172/JCI70559
PMCID: PMC3859382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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