Article

Suppression of early pro-inflammatory senescent signature post-radiotherapy mitigates chronic bone damage

2026-03-03

Abstract excerpt

Cellular senescence has been implicated in the pathophysiology of radiotherapy-related bone loss. Based on our previous work, clearance of senescent cells using genetic and pharmacological tools alleviates the anomalies associated with radiation-associated bone deterioration. The pro-inflammatory senescence associated secretome referred to as senescence associated secretory phenotype (SASP), is a hallmark of cellu...

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Identifiers and source

Literature Corpus work: 500064f4-a443-54ce-8cd5-83d0b09c5612
DOI: 10.64898/2026.03.01.708630

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