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Rb1 haploinsufficiency promotes telomere attrition and radiation-induced genomic instability.

Cancer research - 15 Jul 2013

Gonzalez-Vasconcellos Iria, Anastasov Natasa, Sanli-Bonazzi Bahar, Klymenko Olena, Atkinson Michael J, Rosemann Michael

Abstract excerpt

Germline mutations of the retinoblastoma gene (RB1) predispose to both sporadic and radiation-induced osteosarcoma, tumors characterized by high levels of genomic instability, and activation of alternative lengthening of telomeres. Mice with haploinsufficiency of the Rb1 gene in the osteoblastic lineage reiterate the radiation susceptibility to osteosarcoma seen in patients with germline RB1 mutations. We show...

Topics

Animals
Bone Neoplasms
Cell Cycle Checkpoints
Cells, Cultured
Genes, Retinoblastoma
Genetic Predisposition to Disease
Genomic Instability
Haploinsufficiency
Mice
Osteosarcoma
Radiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Retinoblastoma Protein

Telomere

Source

Identifiers

PMID: 23687339
DOI: 10.1158/0008-5472.CAN-12-3117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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