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Article

Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes.

The Journal of clinical investigation - 1 Apr 2026

Doolittle Madison L, Froemming Mitchell N, Rowsey Jennifer L, Ruan Ming, Sapra Leena, Farr Joshua N, Monroe David G, Khosla Sundeep

Abstract excerpt

Cellular senescence is a heterogeneous phenotype characterized primarily in mesenchymal cells, but the extent to which immune cells differ in their senescence phenotype, or "senotype," is unclear. Here, we applied single-cell approaches alongside both global and cell-specific genetic senolytic mouse models to evaluate the senotype of immune cells in the bone marrow of aging mice. We found that myeloid-lineage...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41592025
DOI: 10.1172/JCI195772
PMCID: PMC13038201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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