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Article

CREG1 enhances p16 INK4a -induced cellular senescence

1 Feb 2011

Abstract excerpt

Cellular senescence is an irreversible growth arrest that is activated in normal cells upon shortening of telomere and other cellular stresses. Bypassing cellular senescence is a necessary step for cells to become immortal during oncogenic transformation. During the spontaneous immortalization of Li-Fraumeni Syndrome (LFS) fibroblasts, we found that CREG1 (Cellular Repressor of E1A-stimulated Genes 1) expression...

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PMID: 21263217
DOI: 10.4161/cc.10.3.14756

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