Article
The importance of senescence in ionizing radiation-induced tumour suppression.
Folia biologica - 1 Jan 2011
Vávrová J, Rezáčová M
Abstract excerpt
Cellular senescence is a condition of longlasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by senescence....
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