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Article

Wnt antagonist SFRP1 functions as a secreted mediator of senescence.

Molecular and cellular biology - 1 Nov 2012

Elzi David J, Song Meihua, Hakala Kevin, Weintraub Susan T, Shiio Yuzuru

Abstract excerpt

Cellular senescence has emerged as a critical tumor suppressive mechanism in recent years, but relatively little is known about how senescence occurs. Here, we report that secreted Frizzled-related protein 1 (SFRP1), a secreted antagonist of Wnt signaling, is oversecreted upon cellular senescence...

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Source

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Identifiers

PMID: 22927647
DOI: 10.1128/MCB.06023-11
PMCID: PMC3486147

Genes

SFRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22927647-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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