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TNKS1BP1 mediates AECII senescence and radiation induced lung injury through suppressing EEF2 degradation

7 Aug 2024

Abstract excerpt

BACKGROUND: Although recent studies provide mechanistic understanding to the pathogenesis of radiation induced lung injury (RILI), rare therapeutics show definitive promise for treating this disease. Type II alveolar epithelial cells (AECII) injury in various manner results in an inflammation response to initiate RILI. RESULTS: Here, we reported that radiation (IR) up-regulated the TNKS1BP1, causing progressive...

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PMID: 39113018
DOI: 10.1186/s12931-024-02914-y

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