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Article

Deconstructing senescence phenotypes in cells of the bone and bone marrow.

The Journal of clinical investigation - 1 Apr 2026

Hofbauer Lorenz C, Rauner Martina

Abstract excerpt

Cellular senescence in osteogenic mesenchymal cells contributes to age-related bone loss. The bone marrow hosts myeloid cells, the precursors of immune cells, as well as mesenchymal cells, which give rise to osteoblasts and osteocytes. The senotype and senolytic response of bone marrow cells, particularly hematopoietic cells, in age-related bone loss is unclear. In this issue, Doolittle et al. showed that of all...

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Identifiers

PMID: 41919499
DOI: 10.1172/JCI204645
PMCID: PMC13038186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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