Article
ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.
Biochimica et biophysica acta - 1 Aug 2014
Verma Manish, Steer Erin K, Chu Charleen T
Abstract excerpt
The leucine rich repeat kinase 2 (LRRK2/dardarin) is implicated in autosomal dominant familial and sporadic Parkinson's disease (PD); mutations in LRRK2 account for up to 40% of PD cases in some populations. LRRK2 is a large protein with a kinase domain, a GTPase domain, and multiple potential protein interaction domains. As such, delineating the functional pathways for LRRK2 and mechanisms by which PD-linked...
Topics
- Animals
- Extracellular Signal-Regulated MAP Kinases
- Humans
- Models, Biological
- Mutation
- Parkinson Disease
- Protein Serine-Threonine Kinases
- Wnt Signaling Pathway