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Article

Molecular characterization of inter-telomere and intra-telomere mutations in human ALT cells.

Nature genetics - 1 Mar 2002

Varley Helen, Pickett Hilda A, Foxon Jennifer L, Reddel Roger R, Royle Nicola J

Abstract excerpt

Telomeres in most immortal cells are maintained by the enzyme telomerase, allowing cells to divide indefinitely. Some telomerase-negative tumors and immortal cell lines maintain long heterogeneous telomeres by the ALT (alternative lengthening of telomeres) mechanism; such tumors are expected to be resistant to anti-telomerase drug therapies. Occasionally telomerase-negative Saccharomyces cerevisiae mutants...

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Identifiers

PMID: 11919561
DOI: 10.1038/ng834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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