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Article

Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands

4 Jan 2017

Abstract excerpt

Alternative lengthening of telomeres (ALT) is a telomerase independent telomere maintenance mechanism that occurs in ∼15% of cancers. The potential mechanism of ALT is homology-directed telomere synthesis, but molecular mechanisms of how ALT maintains telomere length in human cancer is poorly understood. Here, we generated TERC (telomerase RNA) gene knockouts in telomerase positive cell lines that resulted in...

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PMID: 28082393
DOI: 10.1093/nar/gkw1295

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