Article
Analysis of telomeres and telomerase.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Fajkus Jirí, Dvorácková Martina, Sýkorová Eva
Abstract excerpt
The terminal chromatin structures at the ends of eukaryotic chromosomes, the telomeres, are a focus of intensive research due to their importance for the maintenance of chromosome integrity. Their shortening due to incomplete replication functions as a molecular clock counting the number of cell divisions, and ultimately results in cell-cycle arrest and cellular senescence. Telomere shortening can be compensated...
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