Article
Tongue carcinoma infrequently harbor common actionable genetic alterations.
BMC cancer - 19 Sept 2014
Tan Daniel S W, Wang Weining, Leong Hui Sun, Sew Pui Hoon, Lau Dawn P, Chong Fui Teen, Krisna Sai Sakktee, Lim Tony K H, Iyer N Gopalakrishna
Abstract excerpt
BACKGROUND: Oral tongue squamous cell carcinomas (TSCC) are a unique subset of head and neck cancers with a distinct demographic profile, where up to half of the cases are never smokers. A small proportion of patients with OSCC are known to respond to EGFR TKI. We used a high-sensitivity mass spectrometry-based mutation profiling platform to determine the EGFR mutation status, as well as other actionable...
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