Article
A strategy to determine HLA class II restriction broadly covering the DR, DP, and DQ allelic variants most commonly expressed in the general population.
Immunogenetics - 1 May 2013
McKinney Denise M, Southwood Scott, Hinz Denise, Oseroff Carla, Arlehamn Cecilia S Lindestam, Schulten Veronique, Taplitz Randy, Broide David, Hanekom Willem A, Scriba Thomas J, Wood Robert, Alam Rafeul, Peters Bjoern, Sidney John, Sette Alessandro
Abstract excerpt
Classic ways to determine MHC restriction involve inhibition with locus-specific antibodies and antigen presentation assays with panels of cell lines matched or mismatched at the various loci of interest. However, these determinations are often complicated by T cell epitope degeneracy and promiscuity. We describe a selection of 46 HLA DR, DQ, and DP specificities that provide worldwide population (phenotypic)...
Topics
- Alleles
- Antigen Presentation
- B-Lymphocytes
- Cells, Cultured
- Epitopes
- Genetic Variation
- Genetics, Population
- HLA-DP Antigens
- HLA-DQ Antigens