Article
Alloreactive T Cell Receptor Diversity against Structurally Similar or Dissimilar HLA-DP Antigens Assessed by Deep Sequencing.
Frontiers in immunology - 1 Jan 2018
Arrieta-Bolaños Esteban, Crivello Pietro, Metzing Maximilian, Meurer Thuja, Ahci Müberra, Rytlewski Julie, Vignali Marissa, Yusko Erik, van Balen Peter, Horn Peter A, Falkenburg J H Frederik, Fleischhauer Katharina
Abstract excerpt
T cell alloreactivity is mediated by a self-human leukocyte antigen (HLA)-restricted T cell receptor (TCR) repertoire able to recognize both structurally similar and dissimilar allogeneic HLA molecules (i.e., differing by a single or several amino acids in their peptide-binding groove). We hypothesized that thymic selection on self-HLA molecules could have an indirect impact on the size and diversity of the...
Topics
- Alleles
- Autoantigens
- CD4-Positive T-Lymphocytes
- Clonal Selection, Antigen-Mediated
- Genetic Variation
- HLA-DP Antigens
- HeLa Cells
- High-Throughput Nucleotide Sequencing
- Humans
- Immunophenotyping
- Isoantigens
- Receptors, Antigen, T-Cell, alpha-beta