Article
Increased CXCR4 use of HIV-1 subtype C identified by population sequencing in patients failing antiretroviral treatment compared with treatment-naive patients in Botswana.
AIDS research and human retroviruses - 1 May 2014
Sollerkvist Lotta Pramanik, Gaseitsiwe Simani, Mine Madisa, Sebetso Gaseene, Mphoyakgosi Thongbotho, Diphoko Thabo, Essex Max, Ehrnst Anneka
Abstract excerpt
HIV-1 uses the coreceptors CCR5 and/or CXCR4 for cell entry. Monotropic CCR5-using variants are found early in the infection while CXCR4-using variants may appear after progression to AIDS. CXCR4 use may consist of both monotropic and dualtropic viruses. The viral phenotype is important in evaluating the response to CCR5 inhibitors, a new class of antiviral drugs. The coreceptor use of HIV-1 was investigated...
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