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Article

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC

3 Jan 2011

Abstract excerpt

Self-reactive T cells that escape elimination in the thymus can cause autoimmune pathology, and it is therefore important to understand the structural mechanisms of self-antigen recognition. We report the crystal structure of a T cell receptor (TCR) from a patient with relapsing-remitting multiple sclerosis that engages its self-peptide-major histocompatibility complex (pMHC) ligand in an unusual manner. The TCR...

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Identifiers

PMID: 21199956
DOI: 10.1084/jem.20100725

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