Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The T-cell receptor is not hardwired to engage MHC ligands.

Proceedings of the National Academy of Sciences of the United States of America - 6 Nov 2012

Holland Stephen J, Bartok Istvan, Attaf Meriem, Genolet Raphael, Luescher Immanuel F, Kotsiou Eleni, Richard Ashkenaz, Wang Edward, White Matthew, Coe David J, Chai Jian-Guo, Ferreira Cristina, Dyson Julian

Abstract excerpt

The bias of αβ T cells for MHC ligands has been proposed to be intrinsic to the T-cell receptor (TCR). Equally, the CD4 and CD8 coreceptors contribute to ligand restriction by colocalizing Lck with the TCR when MHC ligands are engaged. To determine the importance of intrinsic ligand bias, the ger...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ Cells

Share to Ligands

Share to Major Histocompatibility Complex

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

Share to Thymus Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 23077253
DOI: 10.1073/pnas.1210882109
PMCID: PMC3494948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23077253-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The T-cell receptor is not hardwired to engage MHC ligands.PMID 23077253Read ↗

Pre–T cell receptors topologically sample self-ligands during thymocyte β-selectionSemantic proximity Read ↗

T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.Semantic proximity Read ↗

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read ↗

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity.Semantic proximity Read ↗

Conserved Biophysical Compatibility Among the Highly Variable Germline-Encoded Regions Shapes TCR-MHC InteractionsSemantic proximity Read ↗

Structural determinants of T-cell receptor bias in immunity.Semantic proximity Read ↗

Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoireSemantic proximity Read ↗

Coevolution of T‐cell receptors with MHC and non‐ MHC ligandsSemantic proximity Read ↗

Structural basis for self‐recognition by autoimmune T ‐cell receptorsSemantic proximity Read ↗

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.Semantic proximity Read ↗

A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHCSemantic proximity Read ↗

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.