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Article

Angiotensin-Converting Enzyme in Smooth Muscle Cells Promotes Atherosclerosis-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016

Chen Xiaofeng, Howatt Deborah A, Balakrishnan Anju, Moorleghen Jessica J, Wu Congqing, Cassis Lisa A, Daugherty Alan, Lu Hong

Abstract excerpt

OBJECTIVE: Angiotensin-converting enzyme (ACE) is present in many cell types of atherosclerotic lesions. This study determined whether ACE activity in endothelial and smooth muscle cells (SMCs), 2 major resident cell types of the aorta, contributes to hypercholesterolemia-induced atherosclerosis. APPROACH AND RESULTS: All study mice were in low-density lipoprotein receptor(-/-) background. To determine the...

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Share to Aorta, Thoracic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypercholesterolemia

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Share to Receptors, LDL

Source

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Identifiers

PMID: 27055902
DOI: 10.1161/ATVBAHA.115.307038
PMCID: PMC4882263

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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